Everything about Hemophilia C totally explained
Haemophilia C is a mild form of
haemophilia affecting both sexes. However, it predominantly occurs in Jews of
Ashkenazi descent. It is the fourth most common
coagulation disorder after
von Willebrand's disease and
haemophilia A and
B. In the
USA it's thought to affect 1 in 100,000 of the adult population, making it 10% less common than haemophillia A.
It is caused by a deficiency of
coagulation factor XI and is distinguished from haemophilia A and B by the fact it doesn't lead to bleeding into the joints. Furthermore, it has
autosomal recessive inheritance, since the gene for factor XI is located on chromosome 4 (close to the prekallikrein gene). Many mutations exist, and the bleeding risk isn't always influenced by the severity of the deficiency. Treatment is usually not necessary, except in relation to
operations, leading to many of those having the condition not being aware of it. In these cases,
fresh frozen plasma or recombinant factor XI may be used, but only if necessary. The afflicted may often suffer nosebleeds, and females can experience heavy
menstrual bleeding. Hemophaelia C was first discovered in a young Ashkenazic Jewish American in the 1950s.
Symptoms
The symptoms of Haemophilia C are the same as those for other forms of Haemophilia, mainly:
- Prolonged bleeding from injuries.
- Frequent or heavy nosebleeds.
- Traces of blood in the urine.
Further Information
Get more info on 'Hemophilia C'.
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